Recent advances in Staphylococcus aureus infection: focus on vaccine development
| Autor: | Rajesh Kumar Jha, Shyam Kumar Mishra, Shamshul Ansari, Ahmed Morad Asaad, Birendra R. Tiwari |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Pharmacology business.industry 030106 microbiology Active immunization medicine.disease_cause 03 medical and health sciences 0302 clinical medicine Infectious Diseases Antibiotic resistance Immunization Preclinical phase Staphylococcus aureus Immunology Monoclonal medicine Pharmacology (medical) 030212 general & internal medicine business |
| Zdroj: | Infection and Drug Resistance. 12:1243-1255 |
| ISSN: | 1178-6973 |
| Popis: | Staphylococcus aureus normally colonizes the nasal cavity and pharynx. After breaching the normal habitat, the organism is able to cause a number of infections at any site of the body. The development of antibiotic resistance has created a global challenge for treating infections. Therefore, protection by vaccines may provide valuable measures. Currently, several vaccine candidates have been prepared which are either in preclinical phase or in early clinical phase, whereas several candidates have failed to show a protective efficacy in human subjects. Approaches have also been made in the development of monoclonal or polyclonal antibodies for passive immunization to protect from S. aureus infections. Therefore, in this review we have summarized the findings of recently published scientific literature to make a concise report. |
| Databáze: | OpenAIRE |
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