Metal-Free Hydroamination of Alkynes: A Mild and Concise Synthesis of Thiazolo[3,2-a]indoles and their Cytotoxic Activity

Autor:	Steven Rhodes, Vishakha Bhave, Ryoga Hojo, Spencer Short, Mukund Jha
Rok vydání:	2019
Předmět:	Metal free 010405 organic chemistry Chemistry Intramolecular force Organic Chemistry Intramolecular cyclization Hydroamination 010402 general chemistry 01 natural sciences Combinatorial chemistry Catalysis 0104 chemical sciences
Zdroj:	Synthesis. 51:4263-4270
ISSN:	1437-210X 0039-7881
DOI:	10.1055/s-0039-1690680
Popis:	A metal-free, mild and efficient method for the synthesis of thiazolo[3,2-a]indoles has been developed starting from indoline-2-thiones. The reaction methodology involves first the formation of thermally labile 2-(prop-2-ynylthio)-1H-indole intermediates, which undergo base-mediated intramolecular hydroamination to produce the title compounds in excellent yields.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0f1a01f4b0bdf3e1dd859370ed50a6c3 https://doi.org/10.1055/s-0039-1690680 Zobrazit plný text záznamu