Broadly applicable polysiloxane-based chiral stationary phase for high-performance liquid chromatography and supercritical fluid chromatography
| Autor: | Edgar C. Nicolas, Gerald J. Terfloth, William H. Pirkle, Kenneth G. Lynam |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
chemistry.chemical_classification
Supercritical carbon dioxide Chromatography Chemistry Silica gel Organic Chemistry General Medicine Polymer Biochemistry High-performance liquid chromatography Supercritical fluid Analytical Chemistry Chiral column chromatography chemistry.chemical_compound Supercritical fluid chromatography Enantiomer |
| Zdroj: | Journal of Chromatography A. 705:185-194 |
| ISSN: | 0021-9673 |
| DOI: | 10.1016/0021-9673(95)00246-j |
| Popis: | A recently reported broad-spectrum chiral selector and two of its homologs were incorporated into polymethyl-hydrosiloxane and each of the polymers was immobilized on silica gel to afford chiral stationary phases (CSPs) useful for the separation of the enantiomers of a wide variety of compounds by HPLC and/or supercritical fluid chromatography (SFC). These CSPs are stable toward normal-phase, reversed-phase, and sub/supercritical fluid conditions and are not adversely affected by addition of carboxylic acids or amines as mobile-phase modifiers. These polymeric CSPs show higher efficiencies and shorter analysis times when used with sub/supercritical carbon dioxide then when used in the HPLC mode. Additionally, some separations are achievable using sub/supercritical carbon dioxide but not when the same column is used in the HPLC mode. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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