| Autor: |
Robert K Munns, Cassandra L Vieira, José E Roybal, Jeffrey A Hurlbut, Thomas R Morrison, Wilbert Shimoda |
| Rok vydání: |
1987 |
| Předmět: |
|
| Zdroj: |
Journal of AOAC INTERNATIONAL. 70:626-630 |
| ISSN: |
0004-5756 |
| DOI: |
10.1093/jaoac/70.4.626 |
| Popis: |
A simple and rapid method is described for the determination of dimetridazole (DMZ) and ipronidazole (IPR) in swine feeds at various levels (0.11-110 ppm). The drugs are released from feed by prewetting with a buffer, followed by extraction with either methanol or methylene chloride, depending on the drug level; if necessary, an acid-base cleanup is used before the liquid chromatographic analysis. The analytes are separated on a C18 column and monitored at 320 nm for detection and quantitation. Recoveries of DMZ from several feed formulations averaged 108% at the 92.8 ppm level with a standard deviation (SD) of 4.00% and a coefficient of variation (CV) of 3.70%, 101% at the 11.2 ppm level with an SD of 11.9% and a CV of 11.8%, and 100% at the 0.112 ppm level with an SD of 9.27% and a CV of 9.25%. Recoveries of IPR averaged 77.1% at the 12.9 ppm level with an SD of 1.75% and a CV of 2.27%; IPR recoveries averaged 35.2% at the 0.129 ppm level with an SD of 3.39% and a CV of 9.63%. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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