Structure-activity relationships in 3-oxo-1,4-benzodiazepine-2-acetic acid GPIIb/IIIa antagonists. The 2-benzazepine series

Autor:	Angela S. Wong, James F. Callahan, William H. Miller, Catherine C.K. Yuan, Raul R. Calvo, Janice A. Vasko-Moser, Thomas W. Ku, Richard E. Valocik, Dennis T. Takata, Richard M. Keenan, Drake S. Eggleston, Michael F. Parker, Southall Linda Sue, S M Hwang, Paul F. Koster, William F. Huffman, Tobias Oregon Yellin, Chet Kwon, Irene N. Uzinskas, Bondinell William E, Fadia E. Ali, Dalia R. Jakas, Andrew J. Nichols, James Samanen, R. Curtis Haltiwanger, Kenneth A. Newlander
Rok vydání:	1996
Předmět:	Benzodiazepine Stereochemistry Gpiib iiia antagonist medicine.drug_class Organic Chemistry Clinical Biochemistry Pharmaceutical Science Biochemistry Benzazepine Acetic acid chemistry.chemical_compound chemistry Drug Discovery medicine Molecular Medicine Methylene Molecular Biology
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 6:2481-2486
ISSN:	0960-894X
DOI:	10.1016/0960-894x(96)00432-5
Popis:	In an investigation of the contribution of N-1 to the binding, antiaggregatory, and oral activity in 3-oxo-1,4-benzodiazepine-2-acetic acid based GPIIb/IIIa antagonists, a series of 2-benzazepine analogs, wherein N-1 of the 1,4-benzodiazepine nucleus has been replaced by a methylene group, was examined.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0ef79983c86eb17cdad500249ba3114f https://doi.org/10.1016/0960-894x(96)00432-5 Zobrazit plný text záznamu Full Text from ScienceDirect