Features of the reaction of 1-amino-2-nitroguanidine with isatins. Synthesis of [1,2,4]triazino[5,6-b]indoles

Autor:	Tamara А. Novikova, Mariya P. Ivanova, S. V. Makarenko, T. P. Efimova
Rok vydání:	2021
Předmět:	chemistry.chemical_compound Nitroguanidine chemistry Isatin Organic Chemistry Nitro Medicinal chemistry
Zdroj:	Chemistry of Heterocyclic Compounds. 57:1002-1006
ISSN:	1573-8353 0009-3122
DOI:	10.1007/s10593-021-03014-1
Popis:	Reactions of 1-amino-2-nitroguanidine with isatins leading to the formation of new β-(2-nitro)guanidinohydrazones of isatin, which exist as E/Z-isomers in regards to the azomethine fragment, were studied. It was found that the conditions of the reactions of 1-amino- 2-nitroguanidine with isatins affect the geometry of the formed hydrazones. Conditions for the cyclization of the obtained (Z)-β-(2-nitro)- guanidinohydrazones leading to 3-nitroimino-containing [1,2,4]triazino[5,6-b]indoles were proposed.
Databáze:	OpenAIRE
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