NMR investigations of forskolin. Complete assignment of proton and carbon NMR spectra and conformational analysis
| Autor: | Herbert Kogler, Hans-Wolfram Fehlhaber |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Proton
Carbon-13 NMR satellite Stereochemistry Chemistry Nuclear Theory Pulse sequence General Chemistry Nuclear magnetic resonance spectroscopy Nuclear Overhauser effect Carbon-13 NMR NMR spectra database Crystallography Proton NMR Physics::Accelerator Physics General Materials Science Nuclear Experiment |
| Zdroj: | Magnetic Resonance in Chemistry. 29:993-998 |
| ISSN: | 1097-458X 0749-1581 |
| DOI: | 10.1002/mrc.1260291004 |
| Popis: | The 1H- and 13C NMR spectra of forskolin have been re-investigated. Assignments are based exclusively on unambiguous carbon–carbon and carbon-proton correlations derived from two-dimensional NMR spectra. Stereo-specific differentiations were deduced from selective proton NOE measurements and the interpretation of vicinal and long-range proton-proton scalar couplings. The proton-proton distances calculated from proton NOE effects fit best with a flattened boat-like conformation of ring C, which is different from the conformation of forskolin in the solid state. |
| Databáze: | OpenAIRE |
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