Immunoradiometric Assay of Circulating C-Reactive Protein: Age-related Values in the Adult General Population
| Autor: | Wolfgang Koenig, Mark B. Pepys, Winston L. Hutchinson, Gordon D.O. Lowe, M. Sund, Margit Fröhlich |
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| Rok vydání: | 2000 |
| Předmět: |
medicine.medical_specialty
Immunoradiometric assay education.field_of_study biology business.industry Biochemistry (medical) Clinical Biochemistry C-reactive protein Population Acute-phase protein Radioimmunoassay Neonatal infection Endocrinology Internal medicine Blood plasma Epidemiology biology.protein Medicine business education |
| Zdroj: | Clinical Chemistry. 46:934-938 |
| ISSN: | 1530-8561 0009-9147 |
| DOI: | 10.1093/clinchem/46.7.934 |
| Popis: | Background: Increased values of C-reactive protein (CRP), the classical acute phase protein, within the range below 5 mg/L, previously considered to be within the reference interval, are strongly associated with increased risk of atherothrombotic events, and are clinically significant in osteoarthritis and neonatal infection. Methods: A robust new polyclonal-monoclonal solid- phase IRMA for CRP was developed, with a range of 0.05–10.0 mg/L. Results: Plasma CRP values in general adult populations from Augsburg, Germany (2291 males and 2203 females; ages, 25–74 years) and Glasgow, Scotland (604 males and 650 females; ages, 25–64 years) were very similar. The median CRP approximately doubled with age, from ∼1 mg/L in the youngest decade to ∼2 mg/L in the oldest, and tended to be higher in females. Conclusion: This extensive data set, the largest such study of CRP, provides valuable reference information for future clinical and epidemiological investigations. |
| Databáze: | OpenAIRE |
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