| Autor: |
Hadis Sheikhi, Fatemeh Zeinali Sehrig, Sahar Asvadi, Marjan Assefi, Zahra Foruzandeh, Hossein Ghahramani Almanghadim, Shahab Masoumi |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Biomedical and Translational Science. 1 |
| ISSN: |
2768-4911 |
| Popis: |
Cancer is still considered a main challenge regarding morbidity and mortality, although an earlier diagnosis through screening programs and more effective cure modalities have led to decreased mortality rates so the development of new genetic editing techniques such as zinc finger and TALENs or CRISPRCas9 has enabled the production of strong animal genetic models that sums up the cooperating oncogenic lesions influencing genes with a confirmed role in the proliferation and formation. This review presents the mechanisms of separate genome-editing approaches and explains each of the common nucleasebased platforms. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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