Effect of verapamil on molecular characteristics of myocardial actomyosin in experimental ischemia
| Autor: | Kaĭfadzhian Ma, Oganesian Ss, Samvelian Vm, Zaminian Ts, Dzhanpoladian Eg |
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| Rok vydání: | 1986 |
| Předmět: |
Control level
medicine.medical_specialty Myocardial ischemia Chemistry Ischemia Actomyosin ATPase macromolecular substances General Medicine Metabolism medicine.disease General Biochemistry Genetics and Molecular Biology Internal medicine Gene expression Biophysics medicine Cardiology Verapamil Atpase reaction medicine.drug |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 101:58-60 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/bf00836076 |
| Popis: | Verapamil was shown to be able to recover a significantly depressed actomyosin ATPase activity of the unaffected left ventricular area in experimental myocardial ischemia. The drug also increased Ca-sensitivity of the ATPase reaction, with the amount of actomyosin components (Tn-1, LCM-1, LCM-2, Tn-C) almost reaching the control level. The possibility of direct interaction of verapamil with Ca-binding sites on actomyosin macromolecule is suggested. Its influence on metabolism and gene expression is not excluded. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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