Effectiveness of aspartate aminotransferase as a marker of periodontal disease in children and adolescents

Autor: Chieko Mitsuhata, Yukiko Konishi, Miyuki Nakaoka, Katsuyuki Kozai, Ayumi Shimada, Yumi Irie
Rok vydání: 2014
Předmět:
Zdroj: Pediatric Dental Journal. 24:17-21
ISSN: 0917-2394
DOI: 10.1016/j.pdj.2013.11.002
Popis: Background Biochemical markers from saliva and gingival crevicular fluid are of interest in preventing periodontal disease. We investigated the possibility of detecting aspartate aminotransferase (AST) levels in children and teenagers, as well as the usefulness of the addition of measurements of N-bezyoyl-DL-arginine-2-naphthylamide (BANA) activity and AST release during regular oral check-ups. Subjects and methods Fifty-four children (33 males; 8–15 years) from the pediatric dental clinic of Hiroshima University Hospital were enrolled. Periodontal conditions were investigated using scores of the community periodontal index (CPI), BANA and AST. Bacterial species were also identified. Results In 51 eligible subjects, 64.7% were CPI 1 and 35.3% were CPI 2, and these subjects were diagnosed as having gingivitis. A high BANA score was increased in the CPI 2 group ( p = 0.022) and the AST score showed a similar trend. All scores of BANA and AST were found in the same CPI. The number of subjects with higher scores of BANA and/or AST increased with increasing age. Conclusions It was possible to measure AST levels in children and teenagers. It is suggested that we provide more specific information to children and their guardian using BANA and AST. Measuring biomarkers during regular oral check-ups could lead to an early diagnosis and intervention to avoid the progression of periodontitis during the childhood and teenage years.
Databáze: OpenAIRE
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