| Autor: |
Francesca Greenstreet, Hernando Martinez Vergara, Sthitapranjya Pati, Laura Schwarz, Matthew Wisdom, Fred Marbach, Yvonne Johansson, Lars Rollik, Theodore Moskovitz, Claudia Clopath, Marcus Stephenson-Jones |
| Rok vydání: |
2022 |
| Popis: |
Animals’ choice behavior is characterized by two main tendencies: taking actions that led to rewards and repeating past actions. Theory suggests these strategies may be reinforced by different types of dopaminergic teaching signals: reward prediction error (RPE) to reinforce value-based associations and movement-based action prediction errors to reinforce value-free repetitive associations. Here we use an auditory-discrimination task in mice to show that movement-related dopamine activity in the tail of the striatum encodes the hypothesized action prediction error signal. Causal manipulations reveal that this prediction error serves as a value-free teaching signal that supports learning by reinforcing repeated associations. Computational modeling and experiments demonstrate that action prediction errors cannot support reward-guided learning but when paired with the RPE circuity they serve to consolidate stable sound-action associations in a value-free manner. Together we show that there are two types of dopaminergic prediction errors that work in tandem to support learning. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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