Summary Report on the ISOBM TD-6 Workshop: Analysis of 20 Monoclonal Antibodies against Sialyl Lewisa and Related Antigens

Autor:	A A Molodyk, R. Madiyalakan, W I Garinther, J Magnani, O. Nilsson, Phil D. Rye, Ekaterina V. Vlasova, K.K. Yeung, A. A. Noujaim, B C Schultes, D L Very, Y Cao, Karin Nilsson, J. Hilgers, Nicolai V. Bovin, J V Freeman, K. Nustad, F.T. Kreutz, A Baryshnikov, H Bell, Lars F. Norum, Mavanur R. Suresh
Rok vydání:	1998
Předmět:	Immunoradiometric assay Research groups biology medicine.drug_class business.industry General Medicine Monoclonal antibody Epitope Blind study Antigen Immunology medicine biology.protein CA19-9 Antibody business
Zdroj:	Tumor Biology. 19:390-420
ISSN:	1423-0380 1010-4283
DOI:	10.1159/000030032
Popis:	The ISOBM TD-6 Workshop is the first international workshop on monoclonal antibodies against the Sialyl Lewisa (SLea) antigen. Eight research groups participated in a blind study to characterize the epitope binding, relative affinity and performance in immunoradiometric assays, of a panel of 20 monoclonal antibodies. The antibodies were tested against a diverse panel of neoglycoconjugates, purified antigens and human serum pools from gastrointestinal malignancies. Epitope specificities were determined for the majority of antibodies in the panel. Cross-reactivity with related saccharide structures was noted in several antibodies. Overall, the results of the TD-6 Workshop show further development of SLea immunoassays may yield yet more specific assays for the detection and management of gastrointestinal and other malignancies.
Databáze:	OpenAIRE
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