Thymomas Express Ryanodine Receptor Epitopes
| Autor: | Johan A. Aarli, Åse Mygland, Nils Erik Gilhus, Katsuhiko Mikoshiba, Goro Kuwajima |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Thymoma
biology Chemistry Ryanodine receptor Cardiac muscle Skeletal muscle musculoskeletal system medicine.disease Molecular biology Epitope Myasthenia gravis medicine.anatomical_structure Polyclonal antibodies hemic and lymphatic diseases cardiovascular system biology.protein medicine Antibody neoplasms tissues |
| Zdroj: | Epithelial Tumors of the Thymus ISBN: 9781489900357 |
| DOI: | 10.1007/978-1-4899-0033-3_28 |
| Popis: | Myasthenia gravis (MG) patients with thymoma have antibodies against the Ca2+release channel of striated muscle, the ryanodine receptor (RyR). Thymomas were examined for immunoreactivity with a panel of polyclonal antibodies against RyR peptides. An antibody raised against a peptide in the transmembrane segment of cardiac and skeletal muscle RyR immunostained thymoma epitehlial cells in sections of 17/23 thymomas, and detected a 40 kDa peptide in membrane fractions of thymoma. The RyR peptide was not detected in normal thymus, tonsil or carcinoma of colon. The results indicate that neoplastic thymoma cells express epitopes shared by skeletal and cardiac muscle RyR. |
| Databáze: | OpenAIRE |
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