Simultaneous determination of six volatile components in Longhu Rendan pills using gas chromatography coupled with triple quadrupole mass spectrometry

Autor:	Li Zhu, Li-Qin Ding, Yueming Ma, Tianming Wang, Rong Shi, Yi-Qun Jia, Hua-Jia Jin
Rok vydání:	2014
Předmět:	Analyte Chromatography General Chemical Engineering Selected reaction monitoring General Engineering Analytical Chemistry Borneol Eugenol chemistry.chemical_compound chemistry Triple quadrupole mass spectrometry Gas chromatography Menthol Anethole
Zdroj:	Anal. Methods. 6:3713-3719
ISSN:	1759-9679 1759-9660
Popis:	Longhu Rendan pills (LRPs) are one of the most widely used traditional Chinese over-the-counter medicines for the prevention and treatment of heat stroke and motion sickness. A rapid and effective GC-MS/MS method for the determination of six volatile active constituents including menthol, borneol, isoborneol, anethole, eugenol and acetyl eugenol in LRPs was developed and validated. The six compounds were separated within 8 min using a VF-WAXms capillary column, and the analytes were quantified using GC-MS/MS in multiple reaction monitoring mode. Good linearity was achieved (r > 0.9973). Variations in the intra- and inter-day precisions of all the analytes were below 4.32%, and the accuracy (92.44% to 103.64%) was evaluated using a recovery test. The method successfully determined six volatile compounds in three batches of LRP samples. The present study offers a highly accurate, sensitive and reliable method for the determination of six volatile active constituents in LRPs to promote the quality control investigation of LRPs.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0ebbd0450a80db914f5ce6bef9b1d869 https://doi.org/10.1039/c4ay00602j Zobrazit plný text záznamu