Preparation and evaluation of carbamazepine loaded fibrous electrospun mats of starch
| Autor: | Mirza Shehzad Baig, Purnima D. Amin, Tarique Ali Meer |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Materials science
Chromatography Scanning electron microscope Starch Pharmaceutical Science Electrospinning Contact angle chemistry.chemical_compound Crystallinity Differential scanning calorimetry Chemical engineering chemistry Solubility Pharmacology Toxicology and Pharmaceutics (miscellaneous) Dissolution |
| Zdroj: | Journal of Pharmaceutical Investigation. 45:301-309 |
| ISSN: | 2093-6214 2093-5552 |
| DOI: | 10.1007/s40005-015-0176-1 |
| Popis: | The preset work deals with preparation of fibrous electrospun mats of starch (FEMOS) carrier, from naive starch, through a process of electrospinning. The developed FEMOS was explored for the solubility enhancement of poorly water soluble drug carbamazepine. Solid state characterization was performed with respect to Fourier transform infra-red spectroscopy, X-ray diffraction, scanning electron microscopy, contact angle determination, dissolution kinetics, and differential scanning calorimetry. Rapid release profiles were observed when the carbamazepine was loaded on FEMOS. This effect may be due to high surface area, improved wettability and reduced crystallinity of the loaded drug on FEMOS. The developed formulation was found to have a similar in vivo performance as compared to marketed formulation Tegretol®. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink