Pulmonary activation of vitamin D3 and preventive effect against interstitial pneumonia
| Autor: | Ichiro Saito, Ichiro Tsujino, Ryoko Ushikoshi-Nakayama, Tomoe Yamazaki, Naoyuki Matsumoto |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Vitamin medicine.medical_specialty Calcitriol Clinical Biochemistry Medicine (miscellaneous) Calcitriol receptor Proinflammatory cytokine 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Fibrosis Internal medicine Pulmonary fibrosis medicine Vitamin D and neurology 030109 nutrition & dietetics Nutrition and Dietetics business.industry medicine.disease respiratory tract diseases Endocrinology chemistry 030211 gastroenterology & hepatology Cholecalciferol business medicine.drug |
| Zdroj: | Journal of Clinical Biochemistry and Nutrition. 65:245-251 |
| ISSN: | 1880-5086 0912-0009 |
| DOI: | 10.3164/jcbn.19-48 |
| Popis: | Calcitriol [1,25(OH)2D3] is usually investigated in studies on the preventive effect of activated vitamin D against interstitial pneumonia. Although cholecalciferol (vitamin D3) can be easily obtained in the diet and has a longer half-life than calcitriol, there have been few investigations of its effect on interstitial pneumonia. We used human pulmonary fibroblast cell lines (HPFCs) and a mouse model of bleomycin-induced pulmonary fibrosis to evaluate whether vitamin D3 was activated in the lungs and had a preventive effect against interstitial pneumonia. Expression of the vitamin D receptor gene and genes for enzymes metabolizing vitamin D was evaluated in two HPFCs, and the suppressive effect of vitamin D3 on induction of inflammatory cytokines was also assessed. Gene expression of the vitamin D receptor and vitamin D-metabolizing enzymes was observed in both human pulmonary fibroblast cell lines. Vitamin D3 suppressed bleomycin-induced expression of inflammatory cytokines and fibrosis markers by the HPFCs. In mice, symptoms of bleomycin-induced pulmonary fibrosis were improved and expression of fibrosis markers/fibrosis inducers was decreased by a high vitamin D3 diet. Vitamin D3 is activated locally in lung tissues, suggesting that high dietary intake of vitamin D3 may have a preventive effect against interstitial pneumonia. |
| Databáze: | OpenAIRE |
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