The role of TNFα in type2 diabetes mellitus
| Autor: | Hadeel Mohamed Saeed Majeed, Ahmed Abdul-Hassan Abbas, Mahmood Shakir Khudair |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Bionatura. 7:1-6 |
| ISSN: | 1390-9355 1390-9347 |
| DOI: | 10.21931/rb/2022.07.02.32 |
| Popis: | Type2 Diabetes mellitus is a chronic and most common form of diabetes characterized by hyperglycemia arising from problems with the utilization or production of insulin. Various agents related to an increased risk of developing T2DM include pro-inflammatory cytokines that are critically associated with the progressive resistance of insulin and the pathogenesis of newly diagnosed T2DM. The study aimed to study a possible association of TNFα serum level in diabetes type2 initiation using enzyme-linked immunosorbent assay (ELISA). In this study, 50 newly diagnosed T2DM patients with an age range between 25 and 70 years were included; in addition to fifty healthy volunteers whose sex and age were matched with the T2DM patient’s group to act as a control, serum samples were collected to estimate serum levels of TNFα by Enzyme-Linked Immunosorbent Assay (ELISA). The TNFα revealed a statistically significantly higher serum level in the newly diagnosed T2DM patients compared with the healthy control group. On the other hand, there is no statistically significant difference between obese and non-obese T2DM. The higher level of TNFα in T2DM patients compared to the control group may have a role in the development and pathogenesis of T2DM. The current study showed an association between the serum TNFα level and newly diagnosed type 2 DM, and this studied marker might help in the prediction of T2DM Keywords. T2DM, TNFα, ELISA |
| Databáze: | OpenAIRE |
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