Enzymatic Deficiency in Monocytes from Patients with Chronic Granulomatous Disease
| Autor: | Marie-Anne Gougerot-Pocidalo, Claude Griscelli, R. A. Harkness, Jacques Hakim, Diego Buriot |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
chemistry.chemical_classification
congenital hereditary and neonatal diseases and abnormalities business.industry Phagocytosis medicine.disease Respiratory burst Enzyme Chronic granulomatous disease chemistry immune system diseases hemic and lymphatic diseases Immunology Medicine Kx antigen business |
| Zdroj: | Advances in Experimental Medicine and Biology ISBN: 9781468480900 |
| DOI: | 10.1007/978-1-4684-8088-7_62 |
| Popis: | Chronic granulomatous disease (CGD) is by convention defined as a disorder involving a high susceptibility to bacterial infection related to the inability of the patient’s neutrophils to increase oxygen consumption, despite normal phagocytosis and normal degranulationl,2. CGD appears to be heterogeneous; most cases show an inherihance pattern typical of X-linkage, but the remainder are of non X-linked variety2. CGD heterogeneity has been further suggested by the lack of membrane components in some CGD patients as kx Antigen in neutrophils or red blood cells3, and b-like cytochrome in neutrophils4,5. In two different patients with CGD it has been possible to induce the oxidative burst, with stimuli other than those used in standard analysis procedure6,7. |
| Databáze: | OpenAIRE |
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