Increase in epidermal ATPase-positive Langerhans cells following topical application of 70% deacetylated chitin (DAC-70) in DNCB-sensitized contact dermatitis in guinea pigs preliminary report
| Autor: | Y Horiuchi, K Nishioka, K Otoyama, K Kifune |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Chemotherapy
Langerhans cell integumentary system biology Epidermis (botany) Erythema business.industry medicine.medical_treatment ATPase Dermatology medicine.disease Molecular biology Guinea pig chemistry.chemical_compound medicine.anatomical_structure Chitin chemistry Immunology medicine biology.protein medicine.symptom business Contact dermatitis |
| Zdroj: | Journal of Dermatological Treatment. 7:101-103 |
| ISSN: | 1471-1753 0954-6634 |
| Popis: | Chitin is a polymer of D-glucosamine, beta-poly-N-acetyl D-glucosamine. The chitin derivative, 70% deacetylated chitin (DAC-70), is immunopotentiating. The present study was conducted to determine the immunoregulatory events in skin following topical application of DAC-70 to DNCB-sensitized contact dermatitis in guinea pigs. On the 3rd day of treatment, DNCB-induced erythema was reduced in all five guinea pigs treated with 10% or 3.5% DAC-70 ointment. On the 7th day of treatment, ATPase-positive Langerhans cell (LC) density in epidermal sheets was 1021 + 131/mm2 (mean + SD) for 10% DAC-70-treated skin, and 1000 + 130/mm2 for 3.5% DAC-70-treated skin, both values exceeding 782 + 65/mm2 for normal epidermis. The value in DAC-70-treated samples was significantly greater (P < 0.01) than in normal epidermis. DAC-70 thus appears to have an immunoregulatory effect by increasing the number of epidermal LCs. |
| Databáze: | OpenAIRE |
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