A General Synthetic Method of Chiral 2-Arylalkanoic Esters via Thermal 1,2-Rearrangement

Autor:	Aiichiro Ori, Yutaka Honda, Gen-ichi Tsuchihashi
Rok vydání:	1987
Předmět:	chemistry.chemical_classification chemistry.chemical_compound Hydrolysis 1 2-rearrangement chemistry Carboxylic acid Acetal Grignard reaction Organic chemistry General Chemistry Aliphatic compound
Zdroj:	Bulletin of the Chemical Society of Japan. 60:1027-1036
ISSN:	1348-0634 0009-2673
DOI:	10.1246/bcsj.60.1027
Popis:	(S)-1-Aryl-2-sulfonyloxy-1-alkanone acetals, prepared from natural ethyl (S)-lactate or (S)-valine (chiral sources) by the use of a Grignard reaction, were rearranged under hydrolytic conditions in the presence of a base to give (S)-2-arylalkanoic esters which, in general, showed much higher pharmacological activities than their antipodes.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0e912789ee5c25048a34b67b5923b011 https://doi.org/10.1246/bcsj.60.1027 Zobrazit plný text záznamu