Efficient, scalable kinetic resolution of cis-4-benzyloxy-2,3-epoxybutanol

Autor:	László Poppe, Ferenc Farkas, Melinda Battancs, Béla Simándi, Angelika Thurner, Ildikó Kmecz, Ferenc Faigl, Viktória Bódai
Rok vydání:	2005
Předmět:	Supercritical carbon dioxide Organic Chemistry Enantioselective synthesis Alcohol Optically active Catalysis Kinetic resolution Inorganic Chemistry chemistry.chemical_compound chemistry Organic chemistry Extraction methods Physical and Theoretical Chemistry Enantiomer Derivative (chemistry)
Zdroj:	Tetrahedron: Asymmetry. 16:3841-3847
ISSN:	0957-4166
DOI:	10.1016/j.tetasy.2005.09.029
Popis:	A new enzyme catalysed kinetic resolution of cis-4-benzyloxy-2,3-epoxybutanol has been reported. Efficient, scalable separation of the optically active alcohol from its ester derivative has been solved with liquid–liquid and solid–liquid extraction methods using commercial organic solvents and supercritical carbon dioxide. cis-4-Benzyloxy-2,3-epoxy-1-butanol enantiomers were applied for the enantioselective synthesis of (2S,3S,1′S)- and (2R,3R,1′R)-3-[2′-(dibenzylamino)-1′-hydroxyethyl]-2-phenyloxetane.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0e847cd26683f36a1eca46555e8a9992 https://doi.org/10.1016/j.tetasy.2005.09.029 Zobrazit plný text záznamu Full Text from ScienceDirect