Radiation-Induced Mutagenesis in Mammalian Cells after Exposure to Accelerated Ions with Different LET
| Autor: | I. V. Koshlan, R. D. Govorun, N. A. Koshlan, P. Blaga, Daria V. Petrova, Yu. V. Bogdanova, Evgeny Krasavin |
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| Rok vydání: | 2020 |
| Předmět: |
Physics
Nuclear and High Energy Physics Radiation biology 010308 nuclear & particles physics Mutagenesis Mutant biology.organism_classification 01 natural sciences Atomic and Molecular Physics and Optics Chinese hamster Ionizing radiation Cell culture Hypoxanthine-guanine phosphoribosyltransferase 0103 physical sciences Biophysics Radiology Nuclear Medicine and imaging Irradiation 010306 general physics |
| Zdroj: | Physics of Particles and Nuclei Letters. 17:85-91 |
| ISSN: | 1531-8567 1547-4771 |
| DOI: | 10.1134/s1547477120010112 |
| Popis: | The mutagenic effect of accelerated heavy charged particles on the Chinese hamster V79 cell line is studied. The induction of HPRT mutations in irradiated cells for a long expression time (up to 45 days) after exposure to radiation with different LET are analyzed. The maximum yield of mutant clones is observed at different expression times, depending on the characteristics of ionizing radiation; in this case, the position of the maximum is shifted toward later time intervals with increasing LET of radiation. |
| Databáze: | OpenAIRE |
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