Activity of Conventional Drugs in Head and Neck Cancer Xenografts
| Autor: | B. J. M. Braakhuis, G. B. Snow |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Cisplatin
Drug Oncology medicine.medical_specialty biology Cyclophosphamide business.industry media_common.quotation_subject Head and neck cancer Cancer medicine.disease biology.organism_classification Bleomycin chemistry.chemical_compound Nude mouse chemistry Internal medicine medicine Cancer research Methotrexate business medicine.drug media_common |
| Zdroj: | Human Tumour Xenografts in Anticancer Drug Development ISBN: 9783642732546 |
| Popis: | Nude mice bearing human head and neck cancer xenografts were treated with 5 anticancer drugs that are active in patients with this type of tumour. Using maximum tolerated dose levels, bleomycin appeared to be the most active drug, with activity in 4/9 lines tested; a growth delay factor of more than 2 (GDF>2) was taken as criterion of activity. 5-Fluorouracil and cyclophosphamide gave only moderate responses (1 |
| Databáze: | OpenAIRE |
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