Intracoronary Bone Marrow–Derived Progenitor Cells in Acute Myocardial Infarction
| Autor: | Albrecht Elsässer, D. G. Mathey, Birgit Assmus, Jiangtao Yu, Volker Schächinger, Tim Suselbeck, Roberto Corti, Torsten Tonn, Sandra Erbs, Werner Haberbosch, Andreas M. Zeiher, Rainer Hambrecht, Christian W. Hamm, Hans Hölschermann, Stefanie Dimmeler |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
medicine.medical_specialty
Ejection fraction business.industry medicine.medical_treatment General Medicine Stroke volume medicine.disease Revascularization Placebo Reperfusion therapy medicine.anatomical_structure Multicenter trial Internal medicine cardiovascular system Cardiology Medicine cardiovascular diseases Myocardial infarction Bone marrow business |
| Zdroj: | New England Journal of Medicine. 355:1210-1221 |
| ISSN: | 1533-4406 0028-4793 |
| DOI: | 10.1056/nejmoa060186 |
| Popis: | Background Pilot trials suggest that the intracoronary administration of autologous progenitor cells may improve left ventricular function after acute myocardial infarction. Methods In a multicenter trial, we randomly assigned 204 patients with acute myocardial infarction to receive an intracoronary infusion of progenitor cells derived from bone marrow (BMC) or placebo medium into the infarct artery 3 to 7 days after successful reperfusion therapy. Results At 4 months, the absolute improvement in the global left ventricular ejection fraction (LVEF) was significantly greater in the BMC group than in the placebo group (mean [±SD] increase, 5.5±7.3% vs. 3.0±6.5%; P = 0.01). Patients with a baseline LVEF at or below the median value of 48.9% derived the most benefit (absolute improvement in LVEF, 5.0%; 95% confidence interval, 2.0 to 8.1). At 1 year, intracoronary infusion of BMC was associated with a reduction in the prespecified combined clinical end point of death, recurrence of myocardial infarction, and any revascularization procedure (P = 0.01). Conclusions Intracoronary administration of BMC is associated with improved recovery of left ventricular contractile function in patients with acute myocardial infarction. Largescale studies are warranted to examine the potential effects of progenitor-cell administration on morbidity and mortality. (ClinicalTrials.gov number, NCT00279175.) |
| Databáze: | OpenAIRE |
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