2D QSAR ANALYSIS OF BLOOD-BRAIN BARRIER PERMEABILITY FOR ORGANIC COMPOUNDS

Autor:	A. P. Kosinskaya, L. N. Ognichenko, T. A. Sidelnikova, Ya. F. Burdina, A. A. Shyrykalova, G. F. Stepanov, A. V. Grekova, I. R. Gridina, E. P. Lebed, V. E. Kuz’min
Rok vydání:	2023
Předmět:	General Medicine
Zdroj:	Odesa National University Herald. Chemistry. 27:13-20
ISSN:	2414-5963 2304-0947
Popis:	The aim of this work is to analyze the influence of the structure of organic compounds on their ability to penetrate the blood-brain barrier (BBB) using the values of LogPS (logarithm of the product of permeability and surface area of metabolism, which is a measure of the transfer of compounds from the blood to the brain and reflects the degree of penetration of the substance into the brain without relative binding to proteins). The study of the permeability of BBB is necessary both for the development of new drugs for which the CNS is a biointerference, and for the development of effective ways of treating diseases of the brain.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0e7ea1f503a4f50563f57501d7b28ac8 https://doi.org/10.18524/2304-0947.2022.3(83).268607 Zobrazit plný text záznamu