Combining Indocyanine Green and Tc99-nanocolloid does not increase the detection rate of sentinel lymph nodes in early stage cervical cancer compared to Indocyanine Green alone
| Autor: | Jan Persson, Celine Lönnerfors, Barbara Geppert, Linnea Ekdahl, Oscar Lührs |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cervical cancer genetic structures business.industry Sentinel lymph node Obstetrics and Gynecology medicine.disease body regions 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Oncology chemistry 030220 oncology & carcinogenesis medicine Lymph Radical Hysterectomy Stage (cooking) Nuclear medicine business Lymph node Indocyanine green Gamma probe |
| Zdroj: | Gynecologic Oncology. 156:335-340 |
| ISSN: | 0090-8258 |
| DOI: | 10.1016/j.ygyno.2019.11.026 |
| Popis: | Objective To investigate whether combining two independent tracers increases the SLN-detection rate in cervical cancer. Methods Consecutive women with early stage cervical cancer planned for a robotic radical hysterectomy or a robotic radical trachelectomy with sentinel lymph node (SLN) detection were included. After cervical injections of Indocyanine green (ICG) and Tc99-nanocolloid (Tc99), near-infrared fluorescence imaging and a gamma probe were used to identify SLNs in the upper and lower paracervical pathways (UPP/LPP). A strict surgical algorithm was adhered to and the SLNs were defined as SLN-ICG, SLN-ICG+Tc99 or SLN-Tc99. In FIGO-stage ≥IA2 cancers a full pelvic lymph node dissection (PLND) was performed after detection of SLNs. The primary endpoint was the SLN detection rate per tracer and combination of tracers. Secondary endpoints were sensitivity and mapping rates of the SLN algorithm per tracer and combination of tracers. Results In the sixty-five analyzed women, the bilateral mapping rate was 98.5% for ICG and 60% for Tc99 (p Conclusion SLN detection rate was significantly higher using ICG compared with Tc99. ICG identified all patients with LNMs. Combining ICG and Tc99 did not improve the bilateral detection rate of SLNs. |
| Databáze: | OpenAIRE |
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