Effect of exercise training on HDL subclasses and cholesterol transfers to HDL in elderly individuals
| Autor: | P G Senger Braga, T M Tavoni, R V Baroni, M N Aldin, M J N N Alves, G A Rocha, A L L Bachi, C E Negrao, M W Vaisberg, F R Freitas, A M Figueiredo Neto, N R T Damasceno, R C Maranhao |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | European Heart Journal. 43 |
| ISSN: | 1522-9645 0195-668X |
| Popis: | Introduction Lifestyle habits play a crucial role on coronary artery disease (CAD) prevention. Exercise training promotes increase of HDL-C and decrease of plasma triglycerides is an important tool against atherogenesis. HDL-C determination evaluates only partially the HDL status and anti-atherosclerotic potential. A number of other parameters also relates HDL metabolism and function with CAD, such as HDL subclass distribution and cholesterol transfer to HDL, that have been reported as impaired in CAD. It is known that exercise training can improve those parameters in young individuals, but it has not been explored whether this effect can also be obtained in elderly subjects undergoing moderate training. Purpose Investigate the effects of regular practice of moderate exercise training on cholesterol transfer to HDL and HDL subclasses distribution in elderly compared to young subjects. Methods 111 healthy subjects were enrolled in this study, as divided in four groups paired by sex: active elderly (AE, n=25), inactive elderly (IE, n=21), active young (AY, n=40) and inactive young (IY, n=25). All subjects performed cardiopulmonary test to determine VO2 peak and answered a questionnaire about exercise practice; only subjects practicing regular training for at least one year were selected to the 2 “active” groups. Blood samples were collected to determine lipid and apolipoprotein profile. Lipid subfractions were measured using the Lipoprint system. Cholesterol transfer to HDL was performed by incubating plasma with a donor lipoprotein-like nanoparticle containing radioactively labeled unesterified (UC) and esterified cholesterol (EC), followed by chemical precipitation and radioactive count. Results Data are shown on Table 1. Higher VO2 peak in both active groups confirmed the effectiveness of the training. HDL-C was higher in AE and AY than in IE and IY; apo A-I was higher in AY than in IY, but AE and IE were equal. UC transfer was higher in AE and AY than in IE and IY, but EC was higher AY than in IY, AE and IE were equal. Large HDL subfraction was higher in AY than in IY, but AE and IE were equal. The intermediate HDL subfraction was higher in AE than in IE. Comparing AE with AY, no differences in UC and EC, as well as HDL subfractions were observed. Conclusion Training had the ability to improve parameters of HDL metabolism not only in young but also in elderly subjects and it is remarkable that, despite their lower VO2 peak, in the AE group the cholesterol transfers and the HDL subfraction profile were similar to those of the AY group. Those results confirm the effectiveness of training to improve HDL anti-atherosclerotic features in the elderly. Funding Acknowledgement Type of funding sources: Foundation. Main funding source(s): Fundação de Amparo à Pesquisa do Estado de São Paulo |
| Databáze: | OpenAIRE |
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