Pharmacokinetics of oxolinic acid in black tiger shrimp, Penaeus monodon Fabricius, and the effect of cooking on residues
| Autor: | Lila Ruangpan, Varin Tanasomwang, Kazuaki Uno, Takahiko Aoki, Walai Kleechaya |
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| Rok vydání: | 2006 |
| Předmět: | |
| Zdroj: | Aquaculture Research. 37:826-833 |
| ISSN: | 1365-2109 1355-557X |
| DOI: | 10.1111/j.1365-2109.2006.01500.x |
| Popis: | This study examined the pharmacokinetics andbioavailability of oxolinic acid (OA) in black tigershrimpPenaeus monodon Fabricius,inbrackishwater(salinity 10gL 1 )at28^291C, after intra-sinus (10mgkg 1 ) and oral (50mgkg ) administration andalso investigated the net changes of OA residuesin the shrimp after cooking (boiling, baking andfrying).The haemolymph concentrations of OAafterintra-sinusdosingwerebestdescribedbyatwo-com-partment open model.The distribution and elimina-tion half-lives were 0.84 and17.7h respectively. Theapparent volume of distributionata steadystate andthe total body clearance were estimated to be2061mL kg 1 and 90.1mLkg h respectively.Thebioavailabilityof OAafteranoraladministrationwas 7.9%. The peak haemolymph concentration,the time to peak haemolymph concentration andthe elimination half-life after oral administrationwere 4.20mgmL 1 ,4h and19.8h respectively. Oxo-linic acid muscle and shell levels increased to amaximum (muscle1.76 mgg 1 and shell 8.17mgg )at 4h post administration and then decreased withthe elimination half-life value of 20.2 and 21.9hrespectively. Residual OA in muscle and shell wasreduced by 20^30% by each cooking procedureexamined.Keywords: pharmacokinetics, oxolinicacid, Pena-eus monodon, black tiger shrimp, bioavailability,cookingIntroductionIn Southeast Asia, intensive shrimp farming has de-veloped rapidly inthelast decade. Blacktiger shrimpPenaeusmonodon Fabriciusisaneconomicallyimpor-tant export inThailand, and the greater part of pro-ductionis consumedbytheUSAandJapan.Recently,diseases caused byVibrio bacteria are a serious pro-blem causing economic damage to theThai shrimpindustry.Toreduce diseaseproblems, awide range ofchemotherapeutics has been used. The use of che-motherapeuticdrugs in shrimpfarmingcan haveanimpact on the aquatic environment and potentiallycause health risks because of drug residues in theshrimpsoldforconsumption.Oneofthemajorenvir-onmental eiects by using antibacterial agents isdevelopment of bacterial resistance. Therefore, theproperuseofdrugsisstronglyrecommendedtoavoidsuch problems. Knowledge of pharmacokinetics andresidue depletion is important to minimize humanrisk associated with drug residues and the environ-mental impactof thedrugs.Currently,oxolinicacid(OA)isthemostcommonlyused agent in Thai shrimp culture farms. The phar-macokineticpro¢leofOAhaspreviouslybeenstudiedin rainbow trout Oncorhynchus mykiss (Walbaum)(Bj˛rklundBHustvedtSKlei-now, Jarboe, Shoemaker & Greenless 1994), Atlanticsalmon Salmo salar L. (Hustvedt, Salte & Vassvik1991;Rogstad,EllingsenSMartinsen& Horsberg1995; Samuelsen, Ervik, Pursell & Smith2000),channelcat¢shIctaluruspunctatusL.(Kleinow |
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