Preparation of Stable Aspirin Washable Ointment

Autor:	Hideki Ono, Kazuhiro Imai, Nobuhiro Yasuno, Susumu Kanda, Shigekazu Watanabe, Masao Tsuchiya
Rok vydání:	1994
Předmět:	Aspirin Chromatography business.industry Crotamiton Glyceryl monostearate eye diseases body regions Solvent stomatognathic diseases Castor oil Medicine Organic chemistry skin and connective tissue diseases business medicine.drug
Zdroj:	Japanese Journal of Hospital Pharmacy. 20:502-508
ISSN:	2185-9477 0389-9098
DOI:	10.5649/jjphcs1975.20.502
Popis:	We examined the effect of the water content in the ointment on the stability of aspirin in an effort to improve the stability of aspirin washable ointment which we previously reported (JJHP 17 335 (1991)). The measurement of water content of ointments showed that the smaller the water content the more stabilized is the aspirin in ointment.The half-life of aspirin in ointment became longer when polyoxyethylenehydrogenated castor oil 60 was used instead of glyceryl monostearate, and isopropanol instead of crotamiton as the aspirin solvent. The aspirin in the ointment comprising of dehydrated ingredients was found to be stable for at least two months even at room temperature.
Databáze:	OpenAIRE
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