Genetic control of autoimmune disease: interactions between xid and Ipr
| Autor: | J D Kemp, J S Cowdery, A D Steinberg, R K Gershon |
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| Rok vydání: | 1982 |
| Předmět: | |
| Zdroj: | The Journal of Immunology. 128:388-392 |
| ISSN: | 1550-6606 0022-1767 |
| DOI: | 10.4049/jimmunol.128.1.388 |
| Popis: | A genetic experiment has been performed in mice to test the B cell "hyperactivity" hypothesis of autoantibody production. A backcross was designed such that some progeny carried both the sex-linked recessive gene xid, which markedly reduces the B cell hyperactivity and autoantibody production seen in NZB mice, and the autosomal recessive gene Ipr, which produces a severe lymphoproliferative/autoimmune disorder in the homozygous animal. The data indicate that although xid does not preclude any measured phenotypic expression of Ipr/Ipr disease, it may play a minor modulatory role. In addition, a background gene or genes in the CBA/N mouse, distinct from xid, modulates T cell proliferation in male backcross progeny. This experiment supports the view that autoimmune phenomena are fundamentally heterogeneous, and may involve complex cellular interactions. |
| Databáze: | OpenAIRE |
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