Hyporetinolemia and acute phase proteins in children with and without xerophthalmia
| Autor: | Yin Lan, Keith P. West, Ward Eisinger, Richard D. Semba, Muhilal, Alfred Sommer, Gantira Natadisastra |
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| Rok vydání: | 2000 |
| Předmět: |
Vitamin
medicine.medical_specialty Nutrition and Dietetics biology business.industry C-reactive protein Retinol Acute-phase protein Medicine (miscellaneous) Retinol Equivalent medicine.disease Placebo Gastroenterology Vitamin A deficiency chemistry.chemical_compound Endocrinology chemistry Internal medicine medicine biology.protein Xerophthalmia business |
| Zdroj: | The American Journal of Clinical Nutrition. 72:146-153 |
| ISSN: | 0002-9165 |
| DOI: | 10.1093/ajcn/72.1.146 |
| Popis: | BACKGROUND The relations among hyporetinolemia, acute phase proteins, and vitamin A status in children are unclear. OBJECTIVE The objective was to examine the relations between acute phase proteins and plasma retinol concentrations in children with and without clinical vitamin A deficiency (Bitot spots and night blindness). DESIGN The study was a nonconcurrent analysis of acute phase protein concentrations and other data from a previous clinical trial. Preschool children, 3-6 y of age, with (n = 118) and without (n = 118) xerophthalmia were assigned to receive oral vitamin A (60 mg retinol equivalent) or placebo and were seen at 5 wk. All children received oral vitamin A (60 mg retinol equivalent) at 5 wk. RESULTS At baseline, alpha(1)-acid glycoprotein (AGP) was elevated in 42.9% and 23.5% (P < 0.003) and C-reactive protein (CRP) was elevated in 17.7% and 13.7% (NS) of children with and without xerophthalmia, respectively. Hyporetinolemia (retinol < 0.7 micromol/L) occurred in 61.0% and 47.4% (P < 0.04) of children with and without xerophthalmia, respectively. A history of fever, a history of cough, and nasal discharge noted on examination were each associated with elevated acute phase proteins. Vitamin A supplementation increased plasma retinol at 5 wk but had no significant effect on concentrations of acute phase proteins. CONCLUSIONS Elevated acute phase protein concentrations and infectious disease morbidity are closely associated during vitamin A deficiency. |
| Databáze: | OpenAIRE |
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