Factors predictive of response to interferon-α therapy in hepatitis C virus infection
| Autor: | Mariko Kobayashi, Kumada Hiromitsu, Arase Yasuji, Satoshi Saitoh, Akihito Tsubota, Kenji Ikeda, Isao Koida, Satomi Iwasaki, Michiyo Hashimoto, Kazuaki Chayama |
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| Rok vydání: | 1994 |
| Předmět: |
medicine.medical_specialty
Univariate analysis Hepatology biology business.industry Hepacivirus Hepatitis C virus Alpha interferon Hepatitis C medicine.disease biology.organism_classification medicine.disease_cause Gastroenterology Internal medicine Immunology medicine Viral disease business Interferon alfa medicine.drug |
| Zdroj: | Hepatology. 19:1088-1094 |
| ISSN: | 1527-3350 0270-9139 |
| Popis: | To determine the patient-dependent and virus-related factors that may predict sustained response to interferon-α therapy, we prospectively evaluated 60 consecutive patients with chronic hepatitis C who received a standardized treatment schedule of interferon-α. Twenty-eight patients achieved a long-term sustained remission, 14 patients had temporary responses during treatment but relapsed after completing it and 14 patients did not respond. Four patients dropped out because of severe side effects and were excluded from evaluation of efficacy. Twenty-one variables were chosen as possible predictors of sustained response and were analyzed by means of multi-variate analysis. Variables related to the hepatitis C virus included genotype and concentration in serum before treatment. The former was determined by means of the polymerase chain reaction with genotype-specific primers for genotypes PT, K1, K2a and K2b, which were deduced from nonstructural region 5 of the hepatitis C virus genome. The latter was measured with a competitive polymerase chain reaction technique. Three variables were statistically significant (p |
| Databáze: | OpenAIRE |
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