Unusual regioselective reaction of 2,6-dichloro-4-methylnicotinonitrile with malononitrile dimer

Autor:	N. A. Aksenov, I. G. Dmitrieva, Inna V. Aksenova, V. V. Dotsenko, Vyacheslav Muraviev, L. V. Dyadyuchenko
Rok vydání:	2021
Předmět:	chemistry.chemical_compound chemistry Dimer Chlorine atom Nucleophilic substitution Regioselectivity General Chemistry Medicinal chemistry Triethylamine Malononitrile
Zdroj:	Russian Chemical Bulletin. 70:1363-1367
ISSN:	1573-9171 1066-5285
DOI:	10.1007/s11172-021-3224-1
Popis:	The reaction of 2,6-dichloro-4-methylnicotinonitrile with malononitrile dimer in the presence of triethylamine leads to regioselective nucleophilic substitution of the chlorine atom at position 6 with the formation of triethylammonium 2-amino-3-(6-chloro-5-cyano-4-methyl-pyridin-2-yl)-1,1,3-tricyanoprop-2-en-1-ide. The structure of the product was confirmed by spectral methods and X-ray diffraction analysis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0e35bd60439d729bdf62a897bb35d672 https://doi.org/10.1007/s11172-021-3224-1 Zobrazit plný text záznamu Full text from SpringerLink