Hepcidin levels and gastric cancer risk in the EPIC-EurGast study
Autor: | Núria Aranda, Bodil Ohlsson, Francesca Fasanelli, Heiner Boeing, Antonio Agudo, Ana Fonseca-Nunes, Fulvio Ricceri, Rosario Tumino, Domenico Palli, Aurora Perez-Cornago, Mazda Jenab, Petra H.M. Peeters, Elisabete Weiderpass, Emilio Sánchez-Cantalejo, José María Huerta, Leila Lujan-Barroso, Rudolf Kaaks, Miren Dorronsoro, H. Bas Bueno-de-Mesquita, Monica Tous, Tilman Kühn, Anja Olsen, Kim Overvad, Kay-Tee Khaw, José Maria Quirós, Klas Sjöberg, Amanda J. Cross, Marc J. Gunter, Antonia Trichopoulou, Vittorio Krogh, Anne Tjønneland, Aurelio Barricarte, Effie Vasilopoulou, Eleni Peppa, Amalia Mattiello, Victoria Arija, Paula Jakszyn |
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Rok vydání: | 2017 |
Předmět: |
0301 basic medicine
Cancer Research medicine.medical_specialty Gastroenterology 03 medical and health sciences 0302 clinical medicine Hepcidin hemic and lymphatic diseases Internal medicine medicine Stomach cancer biology business.industry Stomach Confounding nutritional and metabolic diseases Cancer Odds ratio medicine.disease European Prospective Investigation into Cancer and Nutrition Ferritin 030104 developmental biology Endocrinology medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis biology.protein business |
Zdroj: | International Journal of Cancer. 141:945-951 |
ISSN: | 0020-7136 |
Popis: | Hepcidin is the main regulator of iron homeostasis and dysregulation of proteins involved in iron metabolism has been associated with tumorogenesis. However, to date, no epidemiological study has researched the association between hepcidin levels and gastric cancer risk. To further investigate the relationship between hepcidin levels and gastric cancer risk, we conducted a nested case-control study (EURGAST) within the multicentric European Prospective Investigation into Cancer and Nutrition study. The study included 456 primary incident gastric adenocarcinoma cases and 900 matched controls that occurred during an average of 11 years of follow-up. We measured serum levels of hepcidin-25, iron, ferritin, transferrin and C-reactive protein. Odds ratios (ORs) and 95% confidence intervals (CIs) for the risk of gastric cancer by hepcidin levels were estimated from multivariable conditional logistic regression models. Mediation effect of the ferritin levels on the hepcidin-gastric cancer pathway was also evaluated. After adjusting for relevant confounders, we observed a statistically significant inverse association between gastric cancer and hepcidin levels (OR 5 ng/l = 0.96, 95% CI = 0.93–0.99). No differences were found by tumor localization or histological type. In mediation analysis, we found that the direct effect of hepcidin only represents a nonsignificant 38% (95% CI: −69%, 91%). In summary, these data suggest that the inverse association of hepcidin levels and gastric cancer risk was mostly accounted by ferritin levels. Further investigation including repeated measures of hepcidin is needed to clarify their role in gastric carcinogenesis. |
Databáze: | OpenAIRE |
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