Ciliary neurotrophic factor in patients with age-related cataract

Autor: K. I. Kozlova, Shpak Aa, Alla Guekht, T. A. Druzhkova, A. V. Golovin, Natalia V. Gulyaeva
Rok vydání: 2015
Předmět:
Zdroj: Neurochemical Journal. 9:311-314
ISSN: 1819-7132
1819-7124
DOI: 10.1134/s1819712415040169
Popis: We studied the content of ciliary neurotrophic factor (CNTF) in the lacrimal fluid, the aqueous humor, and the blood serum in 40 patients (40 eyes) with age-related cataracts. Collection of stimulated lacrimal fluid was performed by a pipette on the day preceding surgery; the aqueous humor and the blood were sampled during the phacoemulsification of a cataract. CNTF was measured using an enzyme immunoassay. On average, the concentration of CNTF in patients was 43.0 ± 21.2 pg/mL in the lacrimal fluid, 58.7 ± 26.4 pg/mL in the aqueous humor, and 4.4 ± 2.6 pg/mL in the blood serum. The concentration of CNTF in the aqueous humor correlated well with its content in the lacrimal fluid (Pearson’s correlation coefficient was 0.66, P < 0.000) and exceeded it on average by a factor of 1.4 ± 0.5. The data we obtained may be used for an approximate evaluation of the CNTF concentration in the aqueous humor on the basis of an analysis of the lacrimal fluid.
Databáze: OpenAIRE