Orbital extramedullary leukemia relapse in a pediatric patient post‐CART cell therapy—Case report
| Autor: | Abdulrahman Alsultan, Mohammed F. Essa |
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| Rok vydání: | 2020 |
| Předmět: |
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Transplantation medicine.medical_specialty business.industry medicine.medical_treatment medicine.disease Extramedullary leukemia Pathophysiology Surgery Radiation therapy Cell therapy Pediatric patient Refractory immune system diseases Pediatrics Perinatology and Child Health medicine Orbital cellulitis business |
| Zdroj: | Pediatric Transplantation. 25 |
| ISSN: | 1399-3046 1397-3142 |
| Popis: | CART therapy is an approved therapy in advanced ALL. The mechanism of relapse post-CART therapy is under vigorous research. We report a 9-year-old boy who received CD19-CART therapy after BM ALL relapse post-HSCT. He presented with unilateral eye swelling which was initially managed as orbital cellulitis. Later on, it was proven to be an isolated ALL orbital relapse without peripheral blood B-cell detection or BM involvement. Despite radiotherapy, he subsequently developed refractory CD19 positive ALL BM relapse. This case highlights the possibility of unusual relapse sites after CART-therapy and that regular peripheral B-cell monitoring is not enough to assure remission status. Better monitoring tools are needed to detect early disease relapse. Further understanding of the pathophysiology of isolated extramedullary relapse post-CART therapy is warranted to improve the management of such challenging presentations. |
| Databáze: | OpenAIRE |
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