Does RNA secondary structure drive translation or vice versa?
| Autor: | Brian D. Gregory, Marianne C. Kramer |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Untranslated region Regulator Context (language use) Translation (biology) Biology biology.organism_classification Ribosome Cell biology Nucleic acid secondary structure 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Structural Biology Nucleic acid structure Molecular Biology Zebrafish 030217 neurology & neurosurgery |
| Zdroj: | Nature Structural & Molecular Biology. 25:641-643 |
| ISSN: | 1545-9985 1545-9993 |
| DOI: | 10.1038/s41594-018-0100-2 |
| Popis: | The effects of RNA secondary structure on translation have been well recognized; however, the global interplay between both in a dynamic cellular system is poorly understood. Beaudoin, Giraldez and colleagues have analyzed RNA structure dynamics during zebrafish embryonic development and have found that the ribosome unzips mRNA secondary structure during translation, thus leading to a global decrease of structure in highly translated transcripts. Furthermore, the authors establish RNA structure in the 3′ untranslated regions of mRNAs as a major regulator of transcript stability in this context. |
| Databáze: | OpenAIRE |
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