Sequence analysis of HIV-1 isolates from Guinea-Bissau: selection of vaccine epitopes relevant in both West African and European countries
| Autor: | Peter Aaby, Marie Borggren, Betina S Andresen, Joakim Esbjörnsson, Anders Fomsgaard, Gregers J Gram, Lasse Vinner, Eva Maria Fenyö, Henrik Kloverpris, Birgitta G Holmgren, Julie L Hentze, Ingrid Karlsson, Zacarias da Silva, Kristoffer Jarlov Jensen |
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| Rok vydání: | 2011 |
| Předmět: |
Microbiology (medical)
education.field_of_study Subdominant biology Sequence analysis business.industry Population General Medicine Human leukocyte antigen biology.organism_classification Virology Virus Epitope Pathology and Forensic Medicine Vaccination Lentivirus Immunology and Allergy Medicine business education |
| Zdroj: | APMIS. 119:487-497 |
| ISSN: | 0903-4641 |
| DOI: | 10.1111/j.1600-0463.2011.02763.x |
| Popis: | For a CD8 epitope-based vaccine to match different geographic locations, the targeted epitopes for cytotoxic T-lymphocytes (CTLs) must be present in the local circulating HIV-1 strains. Secondly, the vaccine epitopes should match the host population HLA types. We characterized two new HIV-1 isolates from Guinea-Bissau. Also, we have identified 15 subdominant CD8 epitopes representing common HLA super-types theoretically covering most HLA alleles in any population. Herein we demonstrate that the selected vaccine epitopes are well conserved and simultaneously present in sequences from West Africa and Denmark. Use of the selected epitopes will likely ensure ≥10 immune targets in the majority of candidates for experimental therapeutic vaccination in both geographic regions. Our results warrant testing of the selected vaccine epitopes in both geographic locations. |
| Databáze: | OpenAIRE |
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