Relation between vitamin D level and severity, symptomatology and cognitive dysfunction of major depressive disorder—A sample of Egyptian patients
| Autor: | Mohamed A. Khalil, Alaa Afif, Akmal Mostafa, Tamer Goueli, Sandra W. Elseesy |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
business.industry
General Neuroscience Physiology medicine.disease Neuroprotection Decreased Libido vitamin D deficiency 030227 psychiatry Correlation 03 medical and health sciences Psychiatry and Mental health 0302 clinical medicine mental disorders medicine Vitamin D and neurology Major depressive disorder Sex organ Neurology (clinical) business 030217 neurology & neurosurgery Depression (differential diagnoses) |
| Zdroj: | Neurology, Psychiatry and Brain Research. 35:10-15 |
| ISSN: | 0941-9500 |
| Popis: | Background Vitamin D helps in the regulation of neurotransmission and neuroprotection. Therefore, vitamin D deficiency might lead to inactivated receptors and may result in depression. Aim The study assessed the relation between serum level of vitamin D and severity, symptomatology and cognitive dysfunction of Major Depressive Disorder (MDD) in a sample of Egyptian patients. Methods Serum levels of 25-hydroxy vitamin D were measured with electro-chemiluminescence binding assay in 75 patients with MDD. Vitamin D deficiency was described as Results 94.6 % of patients had vitamin D deficiency. There was no significant correlation between levels of vitamin D and severity of depression according to HAM-D. Regarding symptoms of depression, there was a statistically significant difference between levels of vitamin D, being more deficient with genital symptoms: decreased libido and menstrual disturbances. There was no statistically significant correlation between level of vitamin D and cognitive functions. Conclusion MDD was associated with vitamin D deficiency but no statistical significant correlation could be established neither between levels of vitamin D and severity of depression nor between levels of vitamin D and cognitive dysfunction. Vitamin D level was statistically correlated with decreased libido and menstrual disturbances. |
| Databáze: | OpenAIRE |
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