Association between plasma levels of tissue plasminogen activator and postoperative deep vein thrombosis-influence of prophylaxis with a low molecular weight heparin
| Autor: | Christiansen Hm, Henriette S. Neerstrand, Lassen Mr, Olsen Ad, Sørensen Jv, Schøtt P, Lars C. Borris |
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| Rok vydání: | 1990 |
| Předmět: |
medicine.medical_specialty
business.industry medicine.drug_class Deep vein medicine.medical_treatment Low molecular weight heparin Hematology Heparin medicine.disease Tissue plasminogen activator Gastroenterology Thrombosis medicine.anatomical_structure Anesthesia Internal medicine Fibrinolysis medicine business Vein Plasminogen activator medicine.drug |
| Zdroj: | Thrombosis Research. 59:131-138 |
| ISSN: | 0049-3848 |
| DOI: | 10.1016/0049-3848(90)90278-k |
| Popis: | In a prospective, randomized controlled study, tissue plasminogen activator (t-PA) and tissue plasminogen activator antigen (t-PA:ag) were measured pre- and postoperatively in 40 consecutive patients undergoing total hip replacement. Patients received either a subcutaneous injection of low molecular weight heparin or placebo once daily. Deep vein thrombosis was diagnosed by bilateral phlebography. Patients who developed postoperative thromboembolic complications had significantly lower preoperative t-PA activity levels than patients who did not develop such complications. No difference was observed between the two groups with respect to t-PA:ag. Thromboprophylaxis with low molecular weight heparin did not cause any significant changes in t-PA activity and t-PA:ag. This study in high risk patients indicates that impaired fibrinolysis may be associated with development of thromboembolic complications after operation. |
| Databáze: | OpenAIRE |
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