α-Amino acetals containing a phosphonate or phosphine oxide group. Synthesis and reactions with resorcinols

Autor:	M. A. Pudovik, V. V. Syakaev, Dilyara R. Sharafutdinova, L. R. Amirova, Alexander R. Burilov, I. Kh. Rizvanov, Yu. K. Voronina, Airat R. Garifzyanov, E. Yu. Pavlova, L. I. Vagapova
Rok vydání:	2014
Předmět:	Phosphine oxide chemistry.chemical_compound Ternary numeral system chemistry Organic Chemistry Trifluoroacetic acid Oxide Organic chemistry Hydrochloric acid Resorcinol Medicinal chemistry Phosphonate Phosphine
Zdroj:	Russian Journal of Organic Chemistry. 50:469-477
ISSN:	1608-3393 1070-4280
Popis:	New α-amino acetals containing a phosphonate or phosphine oxide group were synthesized by the Kabachnik-Fields reaction in the ternary system amino acetal-paraformaldehyde-dialkyl phosphonate (or dialkylphosphine oxide). Condensation of dialkyl (2,2-dimethoxyethylamino)methylphosphonates with resorcinol and its derivatives in ethanol in the presence of hydrochloric acid, apart from the corresponding 2,2-bis(polyhydroxyphenyl) ethylammonium salts, gave 2,5-bis(polyhydroxyphenyl)-1,4-bis[(dialkoxyphosphoryl)methyl]-piperazines. Dialkyl[(2,2-dimethoxyethylamino)methyl]phosphine oxides (Alk = C8H17, C10H21) did not react with resorcinol derivatives under similar conditions, and analogous ammonium salts were obtained by heating the reactants in boiling trifluoroacetic acid.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0dedf9de57c01e9e2c7c82e8330fbca7 https://doi.org/10.1134/s1070428014040034 Zobrazit plný text záznamu Plný text ve formátu PDF