Parallel Procoagulant and Anticoagulant Pathways for High Molecular Weight Kininogen Coagulant Function

Autor:	Shore Jd, Roberta Sheffer, Steven T. Olson
Rok vydání:	1992
Předmět:	medicine.medical_specialty Heavy chain medicine.drug_class High-molecular-weight kininogen Chemistry Antithrombin Anticoagulant Long-term potentiation Heparin Kallikrein Endocrinology Internal medicine medicine Function (biology) circulatory and respiratory physiology medicine.drug
Zdroj:	Recent Progress on Kinins ISBN: 9783034873239
DOI:	10.1007/978-3-0348-7321-5_32
Popis:	High molecular weight kininogen (HK) or its procoagulant light-chain but not the heavy chain potentiated the heparin enhancement of antithrombin III inactivation of plasma kallikrein and factor XIa from 10-50-fold to approximately 1000-fold at I 0.15, pH 7.4, 25 degrees C. This potentiation resulted in antithrombin becoming a predominant inhibitor of kallikrein and factor XIa in heparinized normal but not HK-deficient plasmas. The heparin chain-length and salt dependence of this potentiation suggested an anticoagulant action of HK analogous to its procoagulant action.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0dec6008ee05250c75d2c570ce229496 https://doi.org/10.1007/978-3-0348-7321-5_32 Zobrazit plný text záznamu