Synthesis of [2-14C] griseolic acid 9′-(4-acetoxy-3-methoxybenzyl)ester, a antiglaucoma agent
| Autor: | Isamu Mikoshiba, Susumu Sato, Hirai Koichi, Kenji Kawai |
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| Rok vydání: | 1993 |
| Předmět: |
chemistry.chemical_classification
Bicyclic molecule Organic Chemistry Griseolic acid Prodrug Biochemistry Analytical Chemistry Amidine chemistry.chemical_compound Dicarboxylic acid chemistry Drug Discovery Structural isomer Organic chemistry Radiology Nuclear Medicine and imaging Spectroscopy Derivative (chemistry) |
| Zdroj: | Journal of Labelled Compounds and Radiopharmaceuticals. 33:195-203 |
| ISSN: | 0362-4803 |
| Popis: | Starting from [14C] ethyl orthoformate and amidine derivative 3 derived from griseolic acid in 6 steps, the synthesis of [2-14C] griseolic acid 9′-(4-acetoxy-3-gethoxybenzyl)ester [14C]-2, a promising antiglaucoma agent with its regioisomer [2-14C] griseolic acid 8′-(4-acetoxy-3-gethoxybenzyl)ester 9 and [2-14C] griseolic acid [14C]-1 has been achieved. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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