| Autor: |
Nisa'ur Rosyidah, Hery Suwito, Indrianti Yunita Sari, Septi Rosiana Dewi, Zella Dwipuspita Dahana, Amalia Muti Anggraini, Kautsar Ul Haq, Nuzilatul Muschafi, Fandi Gunawan, Rina Dewi Renjanawati, Sherly Dwi Cicilianingrum, Januardi Wardana |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
THE 14TH JOINT CONFERENCE ON CHEMISTRY 2019. |
| ISSN: |
0094-243X |
| DOI: |
10.1063/5.0005378 |
| Popis: |
Derivatives of 5-benzylidenehydantion are well known of their various attractive bioactivities such as anticancer, antimicrobial, antidiabetic and tyrosinase inhibitor. The preparation methods of 5-benzylidenehydantoin and 5- benzylidenecreatinine derivatives obtained from the reaction between aromatic aldehydes with hydantoin or creatinine using Knoevenagel condensation are discussed. Performing the reactions, we used mixed catalysts system that were Urea– p-Toluene sulfonic acid (Urea-PTSA) and Guanidine hydrochloride–triethylamine (GnHCl-TEA) in polyethylene glycol as solvent. The reaction conditions were suitable for the reaction of aromatic aldehydes attaching electron donating substituent, as well as electron withdrawing substituents. Catalyst system of Urea-PTSA furnished best yield for rich electron aldehydes, while catalyst system of GnHCl-TEA were suitable for poor electron aldehydes and heteroaromatic aldehydes. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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