Syntheses and biological properties of novel aza-podophyllotoxin analogs prossessing pronounced antitumor activity

Autor:	Akihiro Fujii, Yukio Hitotsuyanagi, Keiji Yamagami, Tetsuya Tahara, Yukiyasu Ito, Yoichi Naka
Rok vydání:	1995
Předmět:	Antitumor activity Chemistry Organic Chemistry Clinical Biochemistry Pharmaceutical Science medicine.disease Biochemistry Leukemia Podophyllotoxin In vivo Biological property Drug Discovery medicine Cancer research Molecular Medicine neoplasms Molecular Biology B16 melanoma medicine.drug
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 5:1039-1042
ISSN:	0960-894X
DOI:	10.1016/0960-894x(95)00172-p
Popis:	2,4-Diaza-4-desoxypodophyllotoxin analogs have been synthesized from substituted anilines. Some of them showed promising antitumor activities against vincristine-resistant P388 murine leukemia and B16 melanoma in vivo.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0dde08cbcb13aded67458aa23a4c4e22 https://doi.org/10.1016/0960-894x(95)00172-p Zobrazit plný text záznamu Full Text from ScienceDirect