Regioselective cyclopropanation reactions using iodonium ylides: Synthesis of prostaglandin precursors

Autor:	Om Prakash, Robert M. Moriarty, Liang Guo, Eric J. May
Rok vydání:	1998
Předmět:	Bicyclic molecule Chemistry Cyclopropanation Stereochemistry Organic Chemistry Prostaglandin synthesis Prostaglandin Regioselectivity Biochemistry Catalysis chemistry.chemical_compound Intramolecular force Drug Discovery Stereoselectivity
Zdroj:	Tetrahedron Letters. 39:765-766
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(97)10620-7
Popis:	Iodonium ylides of methyl 3-oxo- trans,trans -6,8-tetradecadienoate ( 1 ) and diprotected methyl 3,5-di(t-butyldimethyl-silyloxy)-2,6,8-tetrahecatrieneoate ( 5 ) undergo regio- and stereoselective intramolecular cyclopropanation with Cu(I)Cl catalysis to form key bicyclo[3.1.0] intermediates for prostaglandin synthesis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0dd4f0e621113cbb40b895f596983740 https://doi.org/10.1016/s0040-4039(97)10620-7 Zobrazit plný text záznamu Full Text from ScienceDirect