FORMULATION, CHARACTERIZATION AND IN-VITRO DISSOLUTION STUDIES OF METADOXINE TABLETS PREPARED BY VARIOUS GRANULATION METHODS

Autor: Prashant L. Pingale
Rok vydání: 2021
Předmět:
Zdroj: Journal of Medical pharmaceutical and allied sciences. 10:2712-2719
ISSN: 2320-7418
DOI: 10.22270/jmpas.v10i2.1066
Popis: Pharmaceutical tablets are robust, flat, or biconvex dishes, according to the Indian Pharmacopoeia. Depending on a range of medicinal substances, they vary in shape and differ greatly in size and weight. In the era of increasing health awareness and strict standards set by regulatory authorities such as the US FDA, WHO, and globalization, it has become mandatory for the producer to launch a product cost-effectively. In the tablet dosage form, two classes of drugs are administered orally. Narrow extensions of the parietal peritoneum that suspend the diaphragm's liver are the right and left coronary ligaments. To produce an effective and reliable product, the drug must have a fine particle size and a large surface area. The tablet coating takes place inside a perforated rotating drum in a controlled atmosphere. Tablets are lifted and turned into the center of the drum from the sides. To make the tablet surface easier to swallow, every tablet surface is exposed to an even amount of deposited/sprayed coating. The purpose of the present investigation is to formulate a tablet of Metadoxine, which improves cognitive impairment and the main psychological symptoms due to occasional or prolonged alcohol abuse, such as aggressiveness, agitation, mood, and behavioral disturbances. The tablets were prepared using direct compression, dry granulation, and wet granulation method and a comparison of the same with an innovator’s product. Keywords: Tablets, Metadoxine, Dry granulation, direct compression, wet granulation.
Databáze: OpenAIRE