MO708: Association of Atherogenic Index of Plasma (AIP) with Mortality in Chinese and Swedish End-Stage Kidney Disease Patients: Results from Two Cohorts

Autor: Kakei Ryu, Zhimin Chen, Abdul Rashid Tony Qureshi, Mohamed Suliman, Franz Peter Barany, Olof Heimbürger, Jianghua Chen, Peter Stenvinkel, Bengt Lindholm
Rok vydání: 2022
Předmět:
Zdroj: Nephrology Dialysis Transplantation. 37
ISSN: 1460-2385
0931-0509
Popis: BACKGROUND AND AIMS Atherogenic index of plasma (AIP), a logarithmically transformed ratio of triglyceride (TG)/high-density lipoprotein cholesterol (HDL-C), is a biomarker of dyslipidemia and cardiovascular disease (CVD) risk. However, its applicability in end-stage kidney disease (ESKD) is not clear. We examined the association of AIP with all-cause and CVD mortality in two cohorts of ESKD patients, one from China and one from Sweden. METHOD In 1276 Chinese incident peritoneal dialysis (PD) patients (median age 50 years, 56% males) and 559 Swedish ESKD patients starting on dialysis (n = 392) or undergoing hemodialysis (n = 109) or PD 58 (median age 58 years, 62% males), baseline AIP and other biochemical and metabolic biomarkers were analysed in relation to mortality during follow-up period of up to 5 years. All-cause and CVD mortality risk were analysed with competing-risk regression models with transplantation as competing risk adjusting for age, sex, smoking, diabetes, serum albumin, hemoglobulin and calendar year. RESULTS Chinese patients [median (IQR) BMI 21 (19–23) kg/m2 TG 1.4 (1.0–1.8) and HDL-C 1.0 (0.9–1.3) mmol/L] compared with Swedish patients [median (IQR) BMI 24 (22–28)] kg/m2 TG 1.6 (1.2–2.2) and HDL-C 1.2 (1.0–1.6) mmol/L] were significantly younger (P CONCLUSION The highest tertile of AIP was independently associated with higher mortality risk in Chinese ESKD patients while it was associated with lower mortality risk in Swedish ESKD patients suggesting that AIP is context dependent, which limits is usefulness as a risk-assessment tool for predicting clinical outcomes in ESKD patients.
Databáze: OpenAIRE
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