The value of EZH2, p27kip1, BMI-1 and MIB-1 on biopsy specimens with low-risk prostate cancer in selecting men with significant prostate cancer at prostatectomy
Autor: | Tineke Wolters, Geert J.L.H. van Leenders, Chris H. Bangma, Kees J. Vissers, Fritz H. Schröder |
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Rok vydání: | 2009 |
Předmět: | |
Zdroj: | BJU International. 106:280-286 |
ISSN: | 1464-410X 1464-4096 |
Popis: | OBJECTIVE To assess the additional prognostic value of the molecular markers EZH2, MIB-1, p27kip1 and BMI-1 on needle biopsies from men with low-risk prostate cancer, as this disease in needle biopsies shows a heterogeneous clinical outcome, and while it is known that the expression of these tissue markers is predictive of the clinical outcome after radical prostatectomy (RP) their value in prostate biopsies is largely unknown. PATIENTS AND METHODS The study included men participating in a screening study, diagnosed with low-risk prostate cancer and subsequently treated with RP. Immunohistochemical staining for EZH2, MIB-1, p27kip1 and BMI-1 on the needle biopsies were (semi)quantitatively scored and expression levels were related to significant disease at RP. Clinical low-risk prostate cancer was defined as a prostate-specific antigen (PSA) level of ≤10 ng/mL, clinical T-stage ≤2, biopsy Gleason score ≤6, a PSA density of 1.0%) in 42% and a low p27kip expression ( |
Databáze: | OpenAIRE |
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