The value of EZH2, p27kip1, BMI-1 and MIB-1 on biopsy specimens with low-risk prostate cancer in selecting men with significant prostate cancer at prostatectomy

Autor: Tineke Wolters, Geert J.L.H. van Leenders, Chris H. Bangma, Kees J. Vissers, Fritz H. Schröder
Rok vydání: 2009
Předmět:
Zdroj: BJU International. 106:280-286
ISSN: 1464-410X
1464-4096
Popis: OBJECTIVE To assess the additional prognostic value of the molecular markers EZH2, MIB-1, p27kip1 and BMI-1 on needle biopsies from men with low-risk prostate cancer, as this disease in needle biopsies shows a heterogeneous clinical outcome, and while it is known that the expression of these tissue markers is predictive of the clinical outcome after radical prostatectomy (RP) their value in prostate biopsies is largely unknown. PATIENTS AND METHODS The study included men participating in a screening study, diagnosed with low-risk prostate cancer and subsequently treated with RP. Immunohistochemical staining for EZH2, MIB-1, p27kip1 and BMI-1 on the needle biopsies were (semi)quantitatively scored and expression levels were related to significant disease at RP. Clinical low-risk prostate cancer was defined as a prostate-specific antigen (PSA) level of ≤10 ng/mL, clinical T-stage ≤2, biopsy Gleason score ≤6, a PSA density of 1.0%) in 42% and a low p27kip expression (
Databáze: OpenAIRE
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